As a biochemist, Iâve always been fascinated by vitamin B12. Itâs one of the most complex molecules your body uses â a true biochemical masterpiece.
In 1964, Dorothy Hodgkin, a pioneering British chemist, won the Nobel Prize in Chemistry for mapping the three-dimensional structure of vitamin B12. Her discovery revealed how this intricate molecule fuels our nerves, red blood cells, and metabolism â and why getting enough of it isnât optional.
Today, we know that B12 is essential for:
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Making healthy red blood cells and DNA
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Protecting your nerves and brain
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Keeping your energy metabolism running efficiently
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Supporting a healthy heart and mood
Unlike most vitamins, B12 is stored mainly in your liver. But once your stores run low, the symptoms can creep up slowly â and some can become irreversible if left too long.
â ïž Signs You May Be Low in Vitamin B12
If youâve been feeling flat, foggy, or tingling in your fingers or feet, your B12 levels may already be sliding.
And if you take long-term medication â such as tablets for reflux, metformin for diabetes, or Mycophenolate (CellCept) for immune conditions â those symptoms are worth paying close attention to.
These everyday medicines can reduce the amount of B12 your body absorbs from food or how well you utilise it. Over time, that can quietly drain your reserves.
Nerve and brain signs
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Tingling, pins and needles, or numbness in the fingertips, toes, or feet
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Burning sensations in the soles or palms
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Feeling off-balance or clumsy when walking
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âElectric shockâ feelings down the spine when bending the neck
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Memory loss, confusion, or brain fog
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Mood changes â low mood, anxiety, irritability
Body signs
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Constant tiredness or exhaustion
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Pale or yellow-tinged skin
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Shortness of breath even on mild activity
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Sore or swollen tongue
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Mouth ulcers or cracks at the corners of your lips
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Fast heartbeat or feeling light-headed
If you notice tingling or numbness in your fingers or feet â thatâs often the first red flag that B12 has dropped too low.
The good news is that these changes are reversible if you catch them early.
đ Everyday Medicines That Can Lower B12
You donât need to know the chemistry â know these common medicines can get in the way of B12:
|
Type of medicine |
What itâs usually for |
Why it matters |
|---|---|---|
|
Reflux or heartburn tablets (LosecÂź, NexiumÂź, SomacÂź and similar) |
Stomach acid control |
They make your stomach less acidic, which means B12 canât be released appropriately from food. |
|
Diabetes tablets (Metformin) |
Type 2 diabetes |
Long-term use can reduce the amount of B12 your gut absorbs. |
|
Immune medication (Mycophenolate / CellCeptÂź) |
Autoimmune conditions or transplant protection |
Can thin or irritate the gut lining, reducing B12 and folate absorption. |
|
Strong antibiotics |
Infections |
Can disturb the âgoodâ gut bacteria that recycle B12. |
|
Older seizure medicines |
Epilepsy |
It can cause your body to use up B12 more quickly. |
|
The pill (higher-estrogen types) |
Birth control |
May be slightly lower B12 over time. |
You donât have to stop these medicines â theyâre essential for your health.
However, if youâve been taking them for months or years, itâs wise to check your B12 levels and keep them topped up.
đż What You Can Do About It
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Top up every week with the proper form.
Not all B12 is equal. Some cheaper supplements use cyanocobalamin, a synthetic form that your body must convert.
The Smart B12 Patch uses methylcobalamin â the active, methylated form your cells recognise instantly. Itâs the form your nerves and brain actually need to function correctly.
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Take it separately from your meds.
Apply your patch at a different time of day from your medications.
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If you eat animal foods, such as meat, fish, eggs, and dairy, they naturally contain B12.
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If youâre vegetarian or vegan, youâll need to rely on fortified foods (like nutritional yeast, plant milks, or cereals) â or a reliable supplement or patch.
Bacteria, not plants, make B12, so even the healthiest plant-based diet can still fall short over time.
Eat or supplement wisely.
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Ask your doctor for a simple blood test.
Checking your B12 once a year can prevent years of symptoms.
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Listen to early signs.
Tingling, brain fog, fatigue, or a low mood could be your bodyâs subtle call for help.
đ§© The Take-Home
B12 isnât just another vitamin â itâs the spark plug for your nerves, brain, and energy.
If youâre taking reflux tablets, diabetes medication, or immune treatments like Mycophenolate, your body may be losing more B12 than you realise.
Keeping your levels topped up with the Smart B12 Patch â powered by methylcobalamin, the biologically active form â can make a real difference to how you think, move, and feel.
Explore the Smart B12 Patch â
đ§ Safe for Kids?
B12 is essential for children too â it supports growth, red blood cell formation, and healthy brain development.
Children usually get enough nutrients from foods like meat, eggs, and dairy, but fussy eaters or those following a plant-based diet may fall short.
Our Smart B12 Patch utilises methylcobalamin, the active form of B12 thatâs gentle and easily absorbed by the body.
Itâs suitable for older children and teens, but if your child is on long-term medication or has ongoing fatigue or tingling, itâs always best to check with your GP before use.